The innate immune system is the first line of host defense against infection and is comprised
of humoral and cellular mechanisms that recognize potential pathogens within minutes or …

Deficiency of human mannose-binding lectin (MBL) caused by mutations in the coding part
of the MBL2 gene is associated with increased risk and severity of infections and …

Mannose-binding lectin (MBL) is a recognition molecule of the lectin pathway of complement
and a key component of innate immunity. MBL variant alleles have been described in the …

Complement activation and inflammation have been suggested in the pathogenesis of
diabetic vascular lesions. We investigated serum mannose‐binding lectin (MBL) levels and …

Sepsis is a polygenic and complex syndrome that is initiated by infection and is
characterized by a systemic inflammatory response. Genetic polymorphisms in the immune …

A low plasma concentration of mannan-binding protein (MBP) impairs opsonisation and
phagocytosis. Three different mutations in the MBP gene have a dominant effect on MBP …

Gestational diabetes is a major public health problem because of its prevalence, its
associated complications during pregnancy, and its increased risk for type 2 diabetes later in …

Genetic factors may predispose critically ill patients to increased risk of developing sepsis.
Mannose-binding lectin (MBL) is an important factor in innate immune defense. We …

Lectin pathway activation of C3 is known to involve target recognition by mannan-binding
lectin (MBL) or ficolins and generation of classical pathway C3 convertase via cleavage of …

The mannose‐binding lectin (MBL) pathway of complement activation is an important
component of innate host defence. Numerous studies have described associations between …