Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Emerging evidence points to the involvement of the brain extracellular matrix (ECM) in the
pathophysiology of schizophrenia (SZ). Abnormalities affecting several ECM components …

Perineuronal nets (PNNs) were shown to be markedly altered in subjects with
schizophrenia. In particular, decreases of PNNs have been detected in the amygdala …

Perineuronal nets (PNNs) are specialized extracellular matrix aggregates surrounding
distinct neuronal populations and regulating synaptic functions and plasticity. Previous …

The extracellular matrix (ECM) plays diverse roles in several physiological and pathological
conditions. In the brain, the ECM is unique both in its composition and in functions …

Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and
glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG) …

Depressive disorders have been shown to be highly influenced by environmental
pathogenic factors, some of which are believed to exert stress on human brain functioning …

Chondroitin sulfate proteoglycans (CSPGs) play important roles in the developing and
mature nervous system, where they guide axons, maintain stable connections, restrict …

Growing evidence points to synaptic pathology as a core component of the pathophysiology
of schizophrenia (SZ). Significant reductions of dendritic spine density and altered …

Chondroitin sulfate and heparan sulfate proteoglycans are major components of the cell
surface and extracellular matrix in the brain. Both chondroitin sulfate and heparan sulfate …