Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …

Although mitochondrial contributions to cancer have been recognised for approximately a
century, given that mitochondrial DNA (mtDNA) is dwarfed by the size of the nuclear genome …

Intercellular communication between cancer cells and other cells in the tumor
microenvironment plays a defining role in tumor development. Tumors contain infiltrates of …

The oxidative phosphorylation (OXPHOS) system is the only structure in animal cells with
components encoded by two genomes, maternally transmitted mitochondrial DNA (mtDNA) …

Epigenetic mechanisms allow cells to fine-tune gene expression in response to
environmental stimuli. For decades, it has been known that mitochondria have genetic …

Replication of mitochondrial DNA is strictly regulated during differentiation and development
allowing each cell type to acquire its required mtDNA copy number to meet its specific needs …

Tumor initiation, progression, and metastasis are tissue context-dependent processes.
Cellular and non-cellular factors provide the selective microenvironment that determines the …

BACKGROUND: Breast cancer (BC) is the second most common cause of death from cancer
in women in the United States. As the molecular mechanism of BC has not yet been …

Mitochondrial DNA copy number is strictly regulated during development as naive cells
differentiate into mature cells to ensure that specific cell types have sufficient copies of …

Background Different cell types possess different copies of mtDNA to support their specific
requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established …