Talaromycosis is an invasive mycosis endemic in tropical and subtropical Asia and is
caused by the pathogenic fungus Talaromyces marneffei. Approximately 17,300 cases of T …

Transition metals such as iron, zinc, copper, and manganese are essential for the growth
and development of organisms ranging from bacteria to mammals. Numerous studies have …

P 1B-ATPases form a distinct evolutionary sub-family of P-type ATPases, transporting
transition metals such as Cu, Zn, Cd, Pb and Co across membranes in a wide range of …

Since copper (Cu) is essential in key physiological oxidation reactions, organisms have
developed strategies for handling Cu while avoiding its potentially toxic effects. Among the …

Haems are metalloporphyrins that serve as prosthetic groups for various biological
processes including respiration, gas sensing, xenobiotic detoxification, cell differentiation …

The transition metal copper is an essential trace element for both prokaryotes and
eukaryotes. However, intracellular free copper has to be strictly limited due to its toxic side …

Human SCO1 and SCO2 are metallochaperones that are essential for the assembly of the
catalytic core of cytochrome c oxidase (COX). Here we show that they have additional …

The ability to produce melanin is a key virulence factor in many fungal pathogens including
the human basidiomycete pathogen Cryptococcus neoformans, a major cause of life …

Photosynthetic organisms are among the earliest life forms on earth and their biochemistry is
strictly dependent on a wide range of inorganic nutrients owing to the use of metal cofactor …

Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …