Clinical and therapeutic considerations for older adults with head and neck cancer

DR Dickstein, AE Powers, D Vujovic… - … Interventions in Aging, 2023 - Taylor & Francis
Approximately 30% of patients with head and neck squamous cell carcinoma (HNSCC) are
at least 70 years of age, and this percentage is expected to increase as the population …

Evaluation of concomitant systemic treatment in older adults with Head and Neck squamous cell carcinoma undergoing definitive Radiotherapy

A Rühle, S Marschner, M Haderlein, A Fabian… - JAMA network …, 2023 - jamanetwork.com
Importance The number of older adults with head and neck squamous cell carcinoma
(HNSCC) is increasing, and these patients are underrepresented in clinical trials. It is …

SPP1 as a key gene in the lymph node metastasis and a potential predictor of poor prognosis in head and neck carcinoma

S Feng, W Yuan, Z Sun, X Guo, J Ling… - Journal of Oral …, 2022 - Wiley Online Library
Background Lymph node metastasis (LNM) is an important cause leading to recurrence and
development of head and neck carcinoma (HNC), with the precise mechanisms unclear …

Clinical predictors of premature radiotherapy terminations in senior adults with oral cavity and laryngeal carcinoma

DJ Cooper, I Travaglia, M Guller, WJ Talcott… - Head & …, 2024 - Wiley Online Library
Introduction The underlying factors that contribute to early radiotherapy (RT) termination are
understudied, especially in the era of hypofractionated treatment regimens. In this …

Outcomes of definitive local therapy with intensity‐modulated radiation therapy in elderly patients≥ 70 years with HPV‐associated oropharyngeal cancer

S Baliga, V Yildiz, R Barve, A Farag… - Journal of Medical …, 2023 - Wiley Online Library
The incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell
carcinoma (OPSCC) is increasing among elderly (≥ 70 years) patients and the optimal …

The role of the soft palate dose regarding normal tissue toxicities in older adults with head and neck cancer undergoing definitive radiotherapy

HC Bitz, I Sachpazidis, J Zou, D Schnell, D Baltas… - Radiation …, 2024 - Springer
Purpose The number of older adults with head and neck squamous cell carcinoma
(HNSCC) is continuously increasing. Older HNSCC patients may be more vulnerable to …

Treatment with (Chemo)-Radiation in old patients ( 76 years of age) with newly diagnosed non-metastatic squamous cell cancer of the head and neck regionreal …

LS Winkler, M Haderlein, S Semrau, D Höfler… - Frontiers in …, 2024 - frontiersin.org
Treatment of patients with squamous cell carcinoma of the head and neck region (HNSCC)
is in focus of a multitude of studies. In those, one patient group, aging 76 and more is mostly …

Higher Rates of Inadequate Adjuvant Radiation Dose Among Older Adults with Head and Neck Cancer

G Raab, C Babu, Y Yu, B Givi, RJ Wong… - The …, 2024 - Wiley Online Library
Objective To determine the rate of inadequate radiotherapy and identify risk factors
associated with inadequate adjuvant radiotherapy for head and neck cancer among older …

Predisposing, Enabling, and Need Factors Driving Palliative Care Use in Head and Neck Cancer

S Fereydooni, C Valdez, L William… - … –Head and Neck …, 2024 - Wiley Online Library
Objective Characterizing factors associated with palliative care (PC) use in patients with
stage III and VI head and neck cancer using Anderson's behavioral model of health service …

Treatment Response of Gingival Squamous-Cell Carcinoma to Palliative Intent Immunotherapy

N Trehan, A Debbas, M Sternick, J Johnson… - Current Oncology, 2023 - mdpi.com
The use of PD-1 immune checkpoint inhibitor medications has become a common practice
in the treatment of recurrent and metastatic head and neck squamous-cell carcinomas …