Major depressive disorder (MDD), which is a leading psychiatric illness across the world,
severely affects quality of life and causes an increased incidence of suicide. Evidence from …

Although chronic stress is an important risk factor for cardiovascular diseases (CVD) onset,
the underlying mechanisms driving such pathophysiological complications remain relatively …

Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life
quality. The main pathogenesis of depression is associated with central nervous system …

The aim of this study was to investigate the relationship between treatment-resistant
depression (TRD) and inflammation in humans and experimental models. For the human …

The tropomyosin/tyrosine receptor kinase B (trkB) and glucocorticoid receptor (GR) regulate
neuron structure and function and the hormonal stress response. Meanwhile, disruption of …

Abstract Ethnopharmacological relevance Danzhi Xiaoyao Powder (DZXY) is a classical
prescription, that has been extensively used in traditional Chinese medicine (TMC) to treat …

In the current investigation, 5-epi-incensole (3) and 5-epi-incensole acetate (5) were
synthesized from the most potent anti-depressant constituents incensole (1) and incensole …

Depression is a neuropsychiatric disorder characterized by altered emotion and cognition.
Alpha lipoic acid (ALA) is a potent natural antioxidant and exhibits neuroprotective effects …

Abstract Background: Mirtazapine (Mtz) has attracted attention for its anti-anxiety properties.
We aimed to explore the impacts of chronic unpredictable stress (CUS) using Mtz treatment …

Depression presents a significant global health burden, necessitating the search for effective
and safe treatments. This investigation aims to assess the antidepressant effect of the …