Big data, big knowledge: big data for personalized healthcare

M Viceconti, P Hunter, R Hose - IEEE journal of biomedical and …, 2015 - ieeexplore.ieee.org
The idea that the purely phenomenological knowledge that we can extract by analyzing
large amounts of data can be useful in healthcare seems to contradict the desire of VPH …

Cerebrospinal fluid mechanics and its coupling to cerebrovascular dynamics

AA Linninger, K Tangen, CY Hsu… - Annual Review of Fluid …, 2016 - annualreviews.org
Cerebrospinal fluid (CSF) is not stagnant but displays fascinating oscillatory flow patterns
inside the ventricular system and reversing fluid exchange between the cranial vault and …

Computational fluid dynamic simulation of human carotid artery bifurcation based on anatomy and volumetric blood flow rate measured with magnetic resonance …

H Gharahi, BA Zambrano, DC Zhu, JK DeMarco… - International journal of …, 2016 - Springer
Blood flow patterns and local hemodynamic parameters have been widely associated with
the onset and progression of atherosclerosis in the carotid artery. Assessment of these …

Engineering hydrogels for affinity-based release of therapeutic proteins

CJ Teal, SP Lu, MS Shoichet - Chemistry of Materials, 2024 - ACS Publications
Therapeutic proteins can treat a myriad of diseases; however, their effectiveness is limited
by short half-lives. Controlled release systems are advantageous because they prolong the …

CNS wide simulation of flow resistance and drug transport due to spinal microanatomy

KM Tangen, Y Hsu, DC Zhu, AA Linninger - Journal of biomechanics, 2015 - Elsevier
Spinal microstructures are known to substantially affect cerebrospinal fluid patterns, yet their
actual impact on flow resistance has not been quantified. Because the length scale of …

Translational approaches for brain delivery of biologics via cerebrospinal fluid

SS Sadekar, M Bowen, H Cai… - Clinical …, 2022 - Wiley Online Library
Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the
tissues of the central nervous system (CNS) by circumventing the blood‐brain barrier and …

Rotating stall observations in a high speed compressor—Part I: Experimental study

J Dodds, M Vahdati - Journal of Turbomachinery, 2015 - asmedigitalcollection.asme.org
In this two-part paper, the phenomenon of part span rotating stall is studied. The objective is
to improve understanding of the physics by which stable and persistent rotating stall occurs …

[HTML][HTML] Altered diastolic flow patterns and kinetic energy in subtle left ventricular remodeling and dysfunction detected by 4D flow MRI

E Svalbring, A Fredriksson, J Eriksson, P Dyverfeldt… - PloS one, 2016 - journals.plos.org
Aims 4D flow magnetic resonance imaging (MRI) allows quantitative assessment of left
ventricular (LV) function according to characteristics of the dynamic flow in the chamber …

[HTML][HTML] A 3D subject-specific model of the spinal subarachnoid space with anatomically realistic ventral and dorsal spinal cord nerve rootlets

LR Sass, M Khani, GC Natividad, RS Tubbs… - Fluids and Barriers of …, 2017 - Springer
Background The spinal subarachnoid space (SSS) has a complex 3D fluid-filled geometry
with multiple levels of anatomic complexity, the most salient features being the spinal cord …

[HTML][HTML] The impact of spinal cord nerve roots and denticulate ligaments on cerebrospinal fluid dynamics in the cervical spine

S Heidari Pahlavian, T Yiallourou, RS Tubbs… - PloS one, 2014 - journals.plos.org
Cerebrospinal fluid (CSF) dynamics in the spinal subarachnoid space (SSS) have been
thought to play an important pathophysiological role in syringomyelia, Chiari I malformation …