Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …

Atherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is
etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke …

Alzheimer's disease (AD) is an age-related disorder characterized by progressive cognitive
decline and dementia. Alzheimer's disease is an increasingly prevalent disease with 5.3 …

Recent epidemiological and clinico-pathologic data suggest overlaps between Alzheimer
disease (AD) and cerebrovascular lesions that may magnify the effect of mild AD pathology …

The concept of reserve in neuroscience maintains that there are aspects of brain structure
and function that can buffer the effects of neuropathology such that the greater the reserve …

Background Prevention of cognitive impairment and dementia is an important public health
goal. Epidemiological evidence shows a relationship between cognitive impairment and …

Background: Dietary factors might modify cognitive decline that results from aging. Fatty
acids, which are limiting factors in brain development, are prime candidates. Objective: We …

Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number
of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Aβ …

Substantial evidence from epidemiological, pathological, and clinical reports suggests that
vascular factors are critical in the pathogenesis of Alzheimer's disease (AD), and changes in …

Background The pathological features of the common neurodegenerative conditions,
Alzheimer's disease (AD), Parkinson's disease and multiple sclerosis are all known to be …