Molecular and cellular basis of genetically inherited skeletal muscle disorders
JJ Dowling, CC Weihl, MJ Spencer - Nature Reviews Molecular Cell …, 2021 - nature.com
Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …
Multi-omics research in sarcopenia: current progress and future prospects
Sarcopenia is a systemic disease with progressive and generalized skeletal muscle
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …
Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms
IM Salamone, M Quattrocelli… - The Journal of …, 2022 - Am Soc Clin Investig
Glucocorticoid steroids are commonly prescribed for many inflammatory conditions, but
chronic daily use produces adverse effects, including muscle wasting and weakness. In …
chronic daily use produces adverse effects, including muscle wasting and weakness. In …
Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α
M Quattrocelli, M Wintzinger, K Miz, DC Levine… - Science …, 2022 - science.org
Exogenous glucocorticoids interact with the circadian clock, but little attention is paid to the
timing of intake. We recently found that intermittent once-weekly prednisone improved …
timing of intake. We recently found that intermittent once-weekly prednisone improved …
Cardiovascular disease in Duchenne muscular dystrophy: overview and insight into novel therapeutic targets
TI Schultz, FJ Raucci Jr, FN Salloum - Basic to Translational Science, 2022 - jacc.org
Duchenne muscular dystrophy (DMD) is a devastating disease affecting approximately 1 in
every 3,500 male births worldwide. Multiple mutations in the dystrophin gene have been …
every 3,500 male births worldwide. Multiple mutations in the dystrophin gene have been …
Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell–derived skeletal muscle in vitro
Duchenne muscular dystrophy (DMD) is a devastating genetic disease leading to
degeneration of skeletal muscles and premature death. How dystrophin absence leads to …
degeneration of skeletal muscles and premature death. How dystrophin absence leads to …
Comparing deflazacort and prednisone in Duchenne muscular dystrophy
WD Biggar, A Skalsky… - Journal of neuromuscular …, 2022 - content.iospress.com
Deflazacort and prednisone/prednisolone are the current standard of care for patients with
Duchenne muscular dystrophy (DMD) based on evidence that they improve muscle strength …
Duchenne muscular dystrophy (DMD) based on evidence that they improve muscle strength …
[HTML][HTML] Dimethyl fumarate modulates the dystrophic disease program following short-term treatment
New medicines are urgently required to treat the fatal neuromuscular disease Duchenne
muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small …
muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small …
Mechanisms and clinical applications of glucocorticoid steroids in muscular dystrophy
M Quattrocelli, AS Zelikovich… - Journal of …, 2021 - content.iospress.com
Glucocorticoid steroids are widely used as immunomodulatory agents in acute and chronic
conditions. Glucocorticoid steroids such as prednisone and deflazacort are recommended …
conditions. Glucocorticoid steroids such as prednisone and deflazacort are recommended …
LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle
Skeletal muscle exhibits remarkable plasticity in response to environmental cues, with stress-
dependent effects on the fast-twitch and slow-twitch fibers. Although stress-induced gene …
dependent effects on the fast-twitch and slow-twitch fibers. Although stress-induced gene …