Polygenic scores in cancer

X Yang, S Kar, AC Antoniou, PDP Pharoah - Nature reviews Cancer, 2023 - nature.com
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …

[HTML][HTML] Interethnic differences in serum lipids and implications for cardiometabolic disease risk in African ancestry populations

AR Bentley, CN Rotimi - Global heart, 2017 - Elsevier
African Americans generally have a healthier lipid profile (lower triglycerides and higher
high-density lipoprotein cholesterol concentration) compared with those of other ethnicities …

Genomics in Egypt: current status and future aspects

EA El-Attar, RM Helmy Elkaffas, SA Aglan… - Frontiers in …, 2022 - frontiersin.org
Egypt is the third most densely inhabited African country. Due to the economic burden and
healthcare costs of overpopulation, genomic and genetic testing is a huge challenge …

The Next Generation Scientist program: capacity-building for future scientific leaders in low-and middle-income countries

G Pillai, K Chibale, EC Constable, AN Keller… - BMC Medical …, 2018 - Springer
Background Scientific and professional development opportunities for early career scientists
in low-and middle-income countries (LMICs) are limited and not consistent. There is a …

The opportunity in African genome resource for precision medicine

S Fatumo - EBioMedicine, 2020 - thelancet.com
There is a critical need to increase and diversify genomic study in the global efforts to
achieving full implementation of precision medicine. Given this central importance of Africa …

Population structure and infectious disease risk in southern Africa

C Uren, M Möller, PD van Helden, BM Henn… - Molecular Genetics and …, 2017 - Springer
The KhoeSan populations are the earliest known indigenous inhabitants of southern Africa.
The relatively recent expansion of Bantu-speaking agropastoralists, as well as European …

The role of human host genetics in tuberculosis resistance

C Kinnear, EG Hoal, H Schurz… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Tuberculosis (TB) remains a public health problem: the latest estimate of new
incident cases per year is a staggering 10.4 million. Despite this overwhelming number, the …

Data mining and biological sample exportation from South Africa: A new wave of bioexploitation under the guise of clinical care?

C Staunton, K Moodley - SAMJ: South African Medical Journal, 2016 - scielo.org.za
In September 2015, the South African (SA) health insurer Discovery announced that, in
partnership with Craig Venter's company Human Longevity Inc., it would provide genetic …

Genomic literacy and awareness of ethical guidance for genomic research in sub-Saharan Africa: how prepared are biomedical researchers?

O Ogunrin, F Taiwo, L Frith - Journal of empirical research on …, 2019 - journals.sagepub.com
Achieving the objectives of rolling out genomic research programs in sub-Saharan Africa
depends on how prepared indigenous biomedical researchers are for this type of research …

[HTML][HTML] Community engagement and feedback of results in the H3Africa AWI-Gen project: Experiences from the Navrongo Demographic and Health Surveillance site …

G Agongo, C Debpuur, L Amenga-Etego… - AAS Open …, 2021 - ncbi.nlm.nih.gov
Community and Public engagement (CE) have gained traction as an ethical best practice for
the conduct of genomics research, particularly in the context of Africa. In the past 10 years …