Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …

G protein-coupled receptors (GPCRs) are a large diverse family of cell surface signaling
receptors implicated in various types of cancers. Several studies indicate that GPCRs control …

Dietary anthocyanin compounds have multiple biological effects, including antioxidant, anti-
inflammatory, and anti-atherosclerotic characteristics. The present study evaluated the anti …

Etomidate (ETO) is a commonly used intravenous anesthetic that has been reported to exert
a tumor suppressive effect in several types of cancer. The present study aimed to investigate …

Adequate oxygen levels are essential for the functioning and maintenance of biological
processes in virtually every cell, albeit based on specific need. Thus, any change in oxygen …

WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular
biological activities through ubiquitination and degradation of its substrates. Recently …

The current study investigated whether hyperoxia may reverse hypoxia‑induced
radioresistance (RR) in cervical cancer. Human HeLa cells exposed to hypoxic, normoxic or …

Mammalian E3 ubiquitin ligases have emerged in recent years as critical regulators of
cellular homeostasis due to their roles in targeting substrate proteins for ubiquitination and …

Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients
and a vehicle to kill cancer cells - PMC Back to Top Skip to main content NIH NLM Logo …

The role of hypoxia-inducible factor (HIF)-1α in the control of proliferation under non-hypoxic
conditions has been investigated in numerous studies, but does not yield a coherent picture …