NETosis: molecular mechanisms, role in physiology and pathology
NV Vorobjeva, BV Chernyak - Biochemistry (Moscow), 2020 - Springer
NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …
Multiple roles for chemokines in neutrophil biology
Chemokines are recognized as the most critical mediators for selective neutrophil
recruitment during inflammatory conditions. Furthermore, they are considered fundamental …
recruitment during inflammatory conditions. Furthermore, they are considered fundamental …
Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory Parabacteroides goldsteinii lipopolysaccharide
Objective Chronic obstructive pulmonary disease (COPD) is a global disease characterised
by chronic obstruction of lung airflow interfering with normal breathing. Although the …
by chronic obstruction of lung airflow interfering with normal breathing. Although the …
Molecular targets for biological therapies of severe asthma
C Pelaia, C Crimi, A Vatrella, C Tinello… - Frontiers in …, 2020 - frontiersin.org
Asthma is a heterogeneous respiratory disease characterized by usually reversible
bronchial obstruction, which is clinically expressed by different phenotypes driven by …
bronchial obstruction, which is clinically expressed by different phenotypes driven by …
Neutrophilia and NETopathy as key pathologic drivers of progressive lung impairment in patients with COVID-19
There is an urgent need for new therapeutic strategies to contain the spread of the novel
coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely …
coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely …
Elastase and exacerbation of neutrophil innate immunity are involved in multi‐visceral manifestations of COVID‐19
JL Guéant, RM Guéant‐Rodriguez, J Fromonot… - Allergy, 2021 - Wiley Online Library
Background Many arguments suggest that neutrophils could play a prominent role in COVID‐
19. However, the role of key components of neutrophil innate immunity in severe forms of …
19. However, the role of key components of neutrophil innate immunity in severe forms of …
Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers
Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …
In vivo evidence for extracellular DNA trap formation
S Yousefi, D Simon, D Stojkov, A Karsonova… - Cell death & …, 2020 - nature.com
Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and
basophils that facilitates the immobilization and killing of invading microorganisms in the …
basophils that facilitates the immobilization and killing of invading microorganisms in the …
Role and therapeutic targeting strategies of neutrophil extracellular traps in inflammation
X Li, S Xiao, N Filipczak, SSK Yalamarty… - International Journal …, 2023 - Taylor & Francis
Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by
neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for …
neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for …
[HTML][HTML] IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils
Understanding the mechanism of protective immunity in the nasal mucosae is central to the
design of more effective vaccines that prevent nasal infection and transmission of Bordetella …
design of more effective vaccines that prevent nasal infection and transmission of Bordetella …