Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Hypoxic environment is an important feature of solid tumors, which comes from the
imbalance of oxygen supply and consumption. Over the past few years, substantial progress …

Nanomaterials that mimic the catalytic activity of natural enzymes in the complex biological
environment of the human body are called nanozymes. Recently, nanozyme systems have …

Even though breast cancer is the most diagnosed cancer among women, treatments are not
always successful in preventing its progression. Recent studies suggest that hypoxia and …

Altered metabolism of cancer cells reshapes the unique tumor microenvironment (TME) with
glucose addiction and high antioxidant levels, resulting in a strong alliance to promote tumor …

Triple-negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer (BC)
for its high aggressiveness, heterogeneity, and hypoxic nature. Based on biological and …

CA4 is a potent microtubule polymerization inhibitor and vascular disrupting agent.
However, the in vivo efficiency of CA4 is limited owing to its poor pharmacokinetics resulting …

Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer
management. Continuing research in the past years aimed at understanding the biology of …

A large number of chemotherapeutic and immunotherapeutic agents have been shown to be
less effective when exposed to a hypoxic solid tumor. The tumor hypoxia microenvironment …

The tumor hypoxic microenvironment is a dynamic status that is closely related to tumor
growth, metastasis, clearance, and recurrence. Hypoxic conditions are present in almost all …