Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
[HTML][HTML] Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective
S Salvioli, MS Basile, L Bencivenga, S Carrino… - Ageing Research …, 2023 - Elsevier
According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …
share the same basic molecular mechanisms, the identification of biomarkers of age that can …
[HTML][HTML] Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
Slower epigenetic aging is associated with exposure to green space (greenness); however,
the longitudinal relationship has not been well studied, particularly in minority groups. We …
the longitudinal relationship has not been well studied, particularly in minority groups. We …
Targeting epigenetics: A novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review
Background: Biological aging may be a robust biomarker of dementia or cognitive
performance. This systematic review synthesized the evidence for an association between …
performance. This systematic review synthesized the evidence for an association between …
[HTML][HTML] DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife
DNA methylation-based (DNAm) measures of biological aging associate with increased risk
of morbidity and mortality, but their links with cognitive decline are less established. This …
of morbidity and mortality, but their links with cognitive decline are less established. This …
[HTML][HTML] Associations of essential trace elements with epigenetic aging indicators and the potential mediating role of inflammation
X Cheng, Y Wei, R Wang, C Jia, Z Zhang, J An, W Li… - Redox Biology, 2023 - Elsevier
Abstract Background Essential trace elements (ETEs) play essential roles in vital functions,
but their effects on epigenetic aging remain poorly understood. Objectives This study aimed …
but their effects on epigenetic aging remain poorly understood. Objectives This study aimed …
[HTML][HTML] Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data
Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
[HTML][HTML] Metal mixtures and DNA methylation measures of biological aging in American Indian populations
K Boyer, A Domingo-Relloso, E Jiang, K Haack… - Environment …, 2023 - Elsevier
Abstract Introduction Native American communities suffer disproportionately from elevated
metal exposures and increased risk for cardiovascular diseases and diabetes. DNA …
metal exposures and increased risk for cardiovascular diseases and diabetes. DNA …