Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Colorectal cancer (CRC) is one of most common malignancies worldwide and its incidence
is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has …

DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as …

The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …

Colorectal cancer (CRC) is one of the most prevalent cancers, with more than one million
new cases every year. In the last few decades, several advancements in therapeutic and …

The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and
function, then further damages the functions and homeostasis of distal organs, leading to …