Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Relapse of myeloproliferative neoplasms (MPNs) after allogeneic hematopoietic stem cell
transplantation (HSCT) is associated with poor outcomes, as therapeutic approaches to …

Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints.
Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and anti-PD-1/PD-L1 …

Immunotherapy for cancer has provided new treatment approaches for malignant tumors,
but there are low rates of response and high rates of resistance. The most recent …

Simple Summary Immunotherapy has become the filar of modern oncological treatment, and
programmed death-ligand 1 expression is one of the primary immune markers assessed by …

Objective The objective of this research was to screen prognostic related genes of thyroid
papillary carcinoma (PTC) by single-cell RNA sequencing (scRNA-seq), to construct the …

单细胞组学技术能够在单细胞分辨率下以高通量, 无偏倚的方式获取单个细胞的基因组, 转录组,
蛋白质组等组学信息, 从而全面准确地表征细胞功能状态, 揭示细胞间异质性以及反映药物治疗 …

In recent years, the emergence and development of single-cell sequencing technologies
have provided unprecedented opportunities to analyze deoxyribonucleic acid, ribonucleic …

Tumors are not a simple aggregate of transformed cells but rather a complicated ecosystem
containing various components, including infiltrating immune cells, tumor-related stromal …

The programmed death receptor 1 (PD1) and its ligand programmed death receptor ligand 1
(PDL1) are the most widely used immune checkpoints in cancer immunotherapy. The …