Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …

The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

While the timing of food intake is important, it is unclear whether the effects of exercise on
energy metabolism are restricted to unique time windows. As circadian regulation is key to …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Metformin is the first-line option for treating newly diagnosed diabetic patients and also
involved in other pharmacological actions, including antitumor effect, anti-aging effect …

Most physiology and behavior of mammalian organisms follow daily oscillations. These
rhythmic processes are governed by environmental cues (eg, fluctuations in light intensity …

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

Abstract Prokineticin-2 (Prok2) is an important secreted protein likely involved in the
pathogenesis of several acute and chronic neurological diseases through currently …

The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals.
Individual SCN neurons in dispersed culture can generate independent circadian …