The skin has long been recognized as a major producer of cytokines, but the keratinocyte as
principal epidermal cell has received less attention as potential source and target of …

IL‐2 receptor (IL‐2R) signalling is critical for normal lymphocyte proliferation, but its role in
cervical cancer is not fully understood. The receptor is composed of three chains: IL‐2α, IL …

Environmental exposure to arsenic is a major public health challenge worldwide. In detailing
the hallmark signs of chronic arsenic exposure, previous studies have shown that epigenetic …

We defined a cytokine mRNA profile of 12 ovarian cancer biopsies, 10 normal/benign
biopsies, six ovarian cancer cell lines and three ovarian cancer xenografts, using RT-PCR …

Canine X-linked severe combined immunodeficiency (XSCID) is due to mutations in the
common gamma chain (γc) gene and is identical clinically and immunologically to human …

Although even “spontaneous” tumours are immunogenic and are commonly infiltrated by
tumour antigen-specific T cells (at least in melanoma), most tumours are not completely …

Malignant pleural mesothelioma is often unresectable at diagnosis, is refractory to cytotoxic
agents and is frequently complicated by pleural effusion. The expected survival range for …

The tumor microenvironment (TME) is a heterogeneous mixture of resident and tumor cells
that maintain close communication through their secretion products. The composition of the …

The IL-2R signaling is critical for normal lymphocyte proliferation. However, the role of the IL-
2 signaling in cervical cancer is not yet fully understood. We show that in IL-2R-expressing …

Introduction 3. IL-2Ralpha's Role in Cancer 3.1. Hematopoietic cancers 3.1. 1. Adult T-cell
leukemia (ATL) 3.1. 2. Acute lymphoblastic leukemia (ALL) 3.1. 3 B-cell chronic lymphocytic …