Prescription drug use is prevalent during pregnancy, yet there is limited knowledge about
maternal-fetal safety and efficacy of this drug use because pregnant individuals have …

Physiologically based pharmacokinetic (PBPK) modelling in pregnancy is a relatively new
approach that is increasingly being used to assess drug systemic exposure in pregnant …

Arachidonic acid (AA), an ω-6 polyunsaturated fatty acid involved in signalling pathways that
drive cell fate decisions, has an enhancing role in the immunomodulatory effect on …

Minimal physiologically‐based pharmacokinetic (mPBPK) models are an alternative to full
physiologically‐based pharmacokinetic (PBPK) models as they offer reduced complexity …

Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact
of inflammation on renal drug transporters remains to be elucidated. We aimed to quantify …

Physiologically based pharmacokinetic modeling (PBPK) could be used to predict changes
in exposure during pregnancy and possibly inform medicine use in pregnancy in situations …

Pregnant women are often complicated with diseases that require treatment with medication.
Most drugs administered to pregnant women are off-label without the necessary dose …

Aims Ampicillin is frequently used in neonates for the treatment of sepsis and as an
intrapartum prophylaxis option for Group B Streptococcus. Pharmacokinetic data to guide …

Physiologically based pharmacokinetic (PBPK) models consist of compartments
representing different tissues. As most models are only verified based on plasma …

Intravenous (IV) cefuroxime and cefazolin are used prophylactically in caesarean sections
(CS). Currently, there are concerns regarding sub-optimal dosing in obese pregnant women …