Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Abstract Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and
hallmarks of aging are identified as key contributors to aging, but improving/reversing these …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Determinants of length of life are not well understood, and therefore increasing lifespan is a
challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial …

One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon
units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key …

This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

The efficacy of immune checkpoint inhibition in inducing death of cancer cells is affected by
the immunosuppressive “cold” tumor microenvironment, which results in a poor response by …

As the global aging process continues to lengthen, aging-related diseases (eg, chronic
obstructive pulmonary disease (COPD), heart failure) continue to plague the elderly …