The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-
angiogenic cancer therapy are major issues in almost all current concepts of both cancer …

Malignant gliomas are the most common malignant primary brain tumors and one of the
most challenging forms of cancers to treat. Despite advances in conventional treatment, the …

Malignant gliomas especially glioblastoma (GBM) are poorly responsive to the current
treatments. Cilengitide (CGT) is a cyclic pentapeptide that demonstrated efficacy for GBM …

Tumor‐associated stromal cells are dynamic characters that endorse the carcinogenic
process in a multitude of ways. The tumor microenvironment plays a crucial role throughout …

Diffuse brain invasion by glioma cells prevents effective surgical or molecular-targeted
therapy and underlies a detrimental outcome. Migrating glioma cells are guided by complex …

Glioblastoma has the poorest prognosis, and is characterized by excessive invasion and
angiogenesis. To determine the invasive mechanisms, we previously used two glioma cell …

We have established a pair of animal models (J3T-1 and J3T-2) with different invasive and
angiogenic phenotypes, and demonstrated that annexin A2 is expressed at higher levels in …

Osteosarcoma is an aggressive bone cancer that has a high propensity for metastasis to the
lungs. Patients with metastatic disease face a very poor prognosis. Therefore, novel …

Glioblastoma is known to secrete high levels of vascular endothelial growth factor (VEGF),
and clinical studies with bevacizumab, a monoclonal antibody to VEGF, have demonstrated …

The formation of tumor vasculature and cell invasion along white matter tracts have pivotal
roles in the development and progression of glioma. A better understanding of the …