As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …

With an estimate of 350 million people chronically infected with the hepatitis B virus (HBV)
worldwide, it is critically important to understand how persistent HBV infection is maintained …

To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

Abstract Background Hepatitis B virus (HBV) is the leading cause of liver cancer, but the
mechanisms by which HBV causes liver cancer are poorly understood and …

Hepatocellular carcinoma (HCC) is the most common histological form of primary liver
cancer, the tumor cells having retained features of hepatocytic differentiation. It is important …

MicroRNAs (miRNAs) are highly conserved small noncoding RNAs participating in
regulation of various cellular processes. Viruses have been shown to utilize cellular miRNAs …

Hepatitis B virus (HBV) is tightly controlled by a number of noncytotoxic mechanisms. This
control occurs within the host hepatocyte at different steps of the HBV replication cycle. HBV …

Chronic infection with hepatitis B virus is associated with a high incidence of liver diseases,
including hepatocellular carcinoma. Hepatitis-B-virus-encoded X antigen (HBxAg) …

Chronic infection with the human hepatitis B virus (HBV) is a global health problem and a
main cause of progressive liver diseases. HBV exhibits a narrow host range, replicating …

Chronic infection by HBV is the leading cause of hepatocellular carcinoma in man. Several
lines of evidence suggest that the viral transactivator HBx plays a critical role in the …