A cell is delimited by numerous borders that define specific organelles. The walls of some
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …

Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope
(NE) that serve as selective gates for macromolecular transport between nucleus and …

Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the
endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha …

Abstract Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor,
detects DNA fragments to trigger an innate immune response. Recently, accumulating …

The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

Abstract cGAS, an innate immune sensor of cellular stress, recognizes double‐stranded
DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage, or …

ABSTRACT The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a
cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and …

The DNA sensor cGAS detects cytosolic DNA and instigates type I interferon (IFN)
expression. Recent studies find that cGAS also localizes in the nucleus and binds the …

Oncogenic human papillomaviruses (HPVs) replicate in differentiating epithelium, causing
5% of cancers worldwide. Like most other DNA viruses, HPV infection initiates after …

Activating stimulator of interferon genes to turn immunologically refractive cold tumor hot is
an exciting therapeutic approach to increase the clinical responsiveness of some human …