Oxidized CaMKII causes cardiac sinus node dysfunction in mice
PD Swaminathan, A Purohit, S Soni… - The Journal of …, 2011 - Am Soc Clin Investig
Sinus node dysfunction (SND) is a major public health problem that is associated with
sudden cardiac death and requires surgical implantation of artificial pacemakers. However …
sudden cardiac death and requires surgical implantation of artificial pacemakers. However …
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
H Dobrzynski, RH Anderson, A Atkinson… - Pharmacology & …, 2013 - Elsevier
It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
[HTML][HTML] Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5
The pacemaker is composed of specialized cardiomyocytes located within the sinoatrial
node (SAN), and is responsible for originating and regulating the heart beat. Recent …
node (SAN), and is responsible for originating and regulating the heart beat. Recent …
HCN4 provides a 'depolarization reserve'and is not required for heart rate acceleration in mice
S Herrmann, J Stieber, G Stöckl, F Hofmann… - The EMBO …, 2007 - embopress.org
Cardiac pacemaking involves a variety of ion channels, but their relative importance is
controversial and remains to be determined. Hyperpolarization‐activated, cyclic nucleotide …
controversial and remains to be determined. Hyperpolarization‐activated, cyclic nucleotide …
[HTML][HTML] Biology of the sinus node and its disease
The sinoatrial node (SAN) is the normal pacemaker of the heart and SAN dysfunction (SND)
is common, but until recently the pathophysiology was incompletely understood. It was …
is common, but until recently the pathophysiology was incompletely understood. It was …
Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice
A Froese, SS Breher, C Waldeyer… - The Journal of …, 2012 - Am Soc Clin Investig
Cardiac pacemaker cells create rhythmic pulses that control heart rate; pacemaker
dysfunction is a prevalent disorder in the elderly, but little is known about the underlying …
dysfunction is a prevalent disorder in the elderly, but little is known about the underlying …
The cardiac pacemaker current
M Baruscotti, A Barbuti, A Bucchi - Journal of molecular and cellular …, 2010 - Elsevier
In mammals cardiac rate is determined by the duration of the diastolic depolarization of
sinoatrial node (SAN) cells which is mainly determined by the pacemaker If current. f …
sinoatrial node (SAN) cells which is mainly determined by the pacemaker If current. f …
The cardiac conduction system
DS Park, GI Fishman - Circulation, 2011 - Am Heart Assoc
The human heart beats 2.5 billion times during a normal lifespan, a feat accomplished by
cells of the cardiac conduction system (CCS). The functional components of the CCS can be …
cells of the cardiac conduction system (CCS). The functional components of the CCS can be …
Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction
Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …
A common Shox2–Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
In humans, atrial fibrillation is often triggered by ectopic pacemaking activity in the
myocardium sleeves of the pulmonary vein (PV) and systemic venous return. The genetic …
myocardium sleeves of the pulmonary vein (PV) and systemic venous return. The genetic …