The mechanisms underlying cardiac automaticity are still incompletely understood and
controversial. Here we report the complete conditional and time-controlled silencing of the …

Several studies of the pacemaker mechanisms in mammalian cells, most of which were
carried out in cells isolated from the rabbit sinoatrial node (SAN), have highlighted the role of …

Heart rate is controlled by the opposing activities of sympathetic and parasympathetic inputs
to pacemaker myocytes in the sinoatrial node (SAN). Parasympathetic activity on nodal …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are key proteins
involved in the initiation and regulation of the heartbeat. Pacemaker cells within the …

Natriuretic peptides (NPs) are best known for their ability to regulate blood vessel tone and
kidney function whereas their electrophysiological effects on the heart are less clear. Here …

The mouse heart is a popular model to study the function and autonomic control of the
specialized cardiac conduction system (CCS). However, the precise identity and anatomical …

The hypothesis that pacemaking results from the action of transmembrane ionic
mechanisms generating repetitive, spontaneous action potentials in myocytes from the …

Novel HCN4 Mutation. Objectives: To conduct a clinical, genetic, and functional analysis of 3
unrelated families with familial sinus bradycardia (FSB). Background: Mutations in the …

Recent studies demonstrated a role of sphingosine-1-phosphate (S1P) in the protection
against the stress of ischemia/reperfusion (I/R) injury. In experiments reported here, we have …

The mouse is widely used as a genetic platform to investigate the molecular mechanisms of
sinoatrial node (SAN) pacemaking. Recently, it has been shown that isolated SAN cells from …