Insulin and insulin-like growth factor 1 (IGF-1) signaling regulate cellular growth and glucose
metabolism in the myocardium. However, their physiological role in the cells of the cardiac …

Heart rhythm disturbances caused by different etiologies may affect pediatric and adult
patients with life-threatening consequences. When pharmacological therapy is ineffective in …

The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like
cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous …

The primary pacemaking activity of the heart is determined by a spontaneous action
potential (AP) within sinoatrial node (SAN) cells. This unique AP generation relies on two …

The understanding of the electrophysiological mechanisms that underlie mechanosensitivity
of the sinoatrial node (SAN), the primary pacemaker of the heart, has been evolving over the …

Engineering efforts of genetically encoded calcium indicators predominantly focused on
enhancing fluorescence changes, but how indicator expression affects the physiology of …

Hyperpolarization-activated ion channels, encoded by four mammalian genes (HCN1-4),
contribute in an important way to the cardiac pacemaker current I f. Here, we describe the …

Atrial fibrillation (AF) associated with fibrosis is characterized by the appearance of
interstitial myofibroblasts. These cells are responsible for the uncontrolled deposition of the …

Ankyrin-B is a multifunctional adapter protein responsible for localization and stabilization of
select ion channels, transporters, and signaling molecules in excitable cells including …

Since the first reports on the isolation and differentiation of stem cells, and in particular since
the early success in driving these cells down a cardiac lineage, there has been interest in …