Recent perspectives on sinoatrial nodal cell (SANC)⁎ function indicate that spontaneous
sarcoplasmic reticulum (SR) Ca2+ cycling, ie an intracellular “Ca2+ clock,” driven by cAMP …

Mutations in the hyperpolarization-activated nucleotide-gated channel 4 (HCN4) are known
to be associated with arrhythmias in which QT prolongation (delayed ventricular …

Aims Sick sinus syndrome is a generalized abnormality of cardiac impulse formation and is
responsible for a large proportion of pacemaker implantations. Although the exact aetiology …

Aerobic capacity decreases with age, in part because of an age-dependent decline in
maximum heart rate (mHR) and a reduction in the intrinsic pacemaker activity of the …

In spite of the fact that the rabbit is being widely used as a laboratory animal in experimental
neurocardiology, neural control of SAN cells in the rabbit heart has been insufficiently …

In many non-excitable and excitable cells, store-operated calcium entry (SOCE) represents
an additional pathway for calcium entry upon Ca2+ store depletion. In a previous study, we …

Loss or dysregulation of the normally precise control of heart rate via the autonomic nervous
system plays a critical role during the development and progression of cardiovascular …

Shox2 plays a vital role in the morphogenesis and physiological function of the sinoatrial
node (SAN), the primary cardiac pacemaker, manifested by the formation of a hypoplastic …

The sinus node (SN) serves as the primary pacemaker of the heart and is the first
component of the cardiac conduction system. Due to its anatomical properties and sample …

Aims This study aimed at characterizing expression and the functional role of the Gjb6 gene,
encoding for connexin 30 (Cx30) protein, in the adult mouse heart. Methods and results The …