The number of medical studies being published is increasing exponentially, and clinicians
must routinely process large amounts of new information. Moreover, the results of individual …

Meta-analyses of data from human studies are invaluable resources in the life sciences and
the methods to conduct these are well documented. Similarly there are a number of benefits …

Background Systematic reviews have been considered as the pillar on which evidence-
based healthcare rests. Systematic review methodology has evolved and been modified …

Systematic reviews are an important method to support evidence‐based decisions in
healthcare (research). Although not yet as common as clinical systematic reviews, the …

In research aimed at improving human health care, animal studies still play a crucial role,
despite political and scientific efforts to reduce preclinical experimentation in laboratory …

The question of how animal studies should be designed, conducted, and analyzed remains
underexposed in societal debates on animal experimentation. This is not only a scientific but …

Laboratory animal studies are used in a wide range of human health related research areas,
such as basic biomedical research, drug research, experimental surgery and environmental …

Background Quercetin, a natural flavonoid, has shown promise as a senolytic agent for
various degenerative diseases. Recently, its protective effect against osteoarthritis (OA), a …

Background: Early-life exposure to bisphenol A (BPA) has been implicated to play a role in
the development of obesity. Objective: A systematic review with meta-analyses of …

Altered cognitive performance is considered an intermediate phenotype mediating early life
adversity (ELA) effects on later-life development of mental disorders, eg depression …