Sex-related differences in the experience of both clinical and experimentally induced pain
have been widely reported. Specifically, females are at greater risk for developing several …

Migraine is a disease for which there is still no defined pathophysiological etiology and few
translational models. The organic nitrate nitroglycerin has been in use as an experimental …

Objective To analyze the genotypes of the promoter region of the serotonin transporter gene
(5‐HTT) in patients with fibromyalgia (FM). Methods Genomic DNA from 62 patients meeting …

Polymorphic regions consisting of a variable number of tandem repeats within intron 2 of the
gene coding for the serotonin transporter protein 5-HTT have been associated with …

The way in which medication overuse transforms episodic migraine into chronic daily
headache is unknown. To search for candidate brain areas involved in this process, we …

Migraine is a neurological disorder that affects the central nervous system causing painful
attacks of headache. A genetic vulnerability and exposure to environmental triggers can …

Although family and twin studies show that there is a genetic component to migraine, no
genes predisposing to common forms of the disorder have been identified. The most …

OBJECTIVES: Serotonin is a key mediator of intestinal peristalsis, and after it is secreted, it is
effectively cleansed from the neuronal gap by means of a high affinity substance called …

Migraine is a complex neurovascular disorder with substantial evidence supporting a
genetic contribution. Prior attempts to localize susceptibility loci for common forms of …

Migraine is a brain disorder characterized by a piercing headache which affects one side of
the head, located mainly at the temples and in the area around the eye. Migraine imparts …