Current first-line treatments for major depressive disorder (MDD), ie, antidepressant drugs
and psychotherapy, show delayed onset of therapeutic effect as late as 2–3 weeks or more …

Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an
action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and …

The conscious experience of pain defies precise anatomic, physiologic, and/or
pharmacologic definition; furthermore, it can be experienced even in the absence of obvious …

Introduction: Neuropathic pain (NP) has several therapeutic options but efficacy is limited
and adverse effects occur, such that additional treatment options are needed. A topical …

Ketamine is a drug largely used in clinical practice as an anesthetic and it can also be used
as an analgesic to manage chronic pain symptoms. Despite its interactions with several …

Background and purpose: The peptide PnPP-19, derived from the spider toxin PnTx2-6
(renamed as δ-CNTX-Pn1c), potentiates erectile function by activating the nitrergic system …

Ketamine has been widely used as an analgesic and produces dissociative anesthetic
effects. The antinociceptive effects of ketamine have been studied, but the involvement of …

Abstract Context: Magnesium and MK-801 (dizocilpine), antagonists of N-methyl-d-aspartate
receptors, are involved in the processing of pain. Objective: This study determines whether …

Bckground Aripiprazole is an antipsychotic drug used to treat schizophrenia and bipolar
disorder. Recently, its peripheral analgesic component was evaluated, however, the …

Dipyrone is an analgesic pro-drug used clinically to control moderate pain with a high
analgesic efficacy and low toxicity. Dipyrone is hydrolyzed to 4-methylaminoantipyrine (4 …