Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in …
FM Commichau, JL Heidemann, R Ficner… - Journal of …, 2019 - Am Soc Microbiol
Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …
Escherichiacoli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions
For cells to grow faster they must increase their protein production rate. Microorganisms
have traditionally been thought to accomplish this increase by producing more ribosomes to …
have traditionally been thought to accomplish this increase by producing more ribosomes to …
Enzyme expression kinetics by Escherichia coli during transition from rich to minimal media depends on proteome reserves
Bacterial fitness depends on adaptability to changing environments. In rich growth medium,
which is replete with amino acids, Escherichia coli primarily expresses protein synthesis …
which is replete with amino acids, Escherichia coli primarily expresses protein synthesis …
[HTML][HTML] Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host …
S Monem, B Furmanek-Blaszk, A Łupkowska… - International Journal of …, 2020 - mdpi.com
Acinetobacter baumannii is considered one of the most persistent pathogens responsible for
nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high …
nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high …
Clarifying the link between toxin–antitoxin modules and bacterial persistence
While most of a bacterial population is killed upon antibiotic exposure, a fraction transiently
exhibits a multidrug-tolerant phenotype termed antibiotic persistence. This phenomenon …
exhibits a multidrug-tolerant phenotype termed antibiotic persistence. This phenomenon …
[HTML][HTML] Coping with stress: how bacteria fine-tune protein synthesis and protein transport
Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …
Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1
To survive under conditions of stress, such as nutrient deprivation, bacterial 70S ribosomes
dimerize to form hibernating 100S particles. In γ-proteobacteria, such as Escherichia coli …
dimerize to form hibernating 100S particles. In γ-proteobacteria, such as Escherichia coli …
Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae
GB Severin, MS Ramliden, LA Hawver… - Proceedings of the …, 2018 - National Acad Sciences
Sensing and responding to environmental changes is essential for bacteria to adapt and
thrive, and nucleotide-derived second messengers are central signaling systems in this …
thrive, and nucleotide-derived second messengers are central signaling systems in this …
High coverage metabolomics analysis reveals phage-specific alterations to Pseudomonas aeruginosa physiology during infection
Phage-mediated metabolic changes in bacteria are hypothesized to markedly alter global
nutrient and biogeochemical cycles. Despite their theoretic importance, experimental data …
nutrient and biogeochemical cycles. Despite their theoretic importance, experimental data …
Making the case for disordered proteins and biomolecular condensates in bacteria
Intrinsically disordered proteins/regions (IDPs/IDRs) contribute to a diverse array of
molecular functions in eukaryotic systems. There is also growing recognition that …
molecular functions in eukaryotic systems. There is also growing recognition that …