Non-viral vectors have emerged as a promising alternative to viral gene delivery systems
due to their safer profile. Among non-viral vectors, recently, niosomes have shown favorable …

Alzheimer's disease is a progressive neurodegenerative disorder characterized by
extracellular amyloid beta peptides and neurofibrillary tangles consisted of intracellular …

Hereditary amyloidosis associated with mutations in the transthyretin gene (hATTR) is a
progressive devastating disease, with a fatal outcome occurring within 10years after onset …

To expand the applicability of recently developed dioxane-and morpholino-based
nucleotide analogues, their seed region destabilizing properties in small interfering RNAs …

Classically, a molecular element (ME) is a pure substance composed of two or more atoms
of the same element. However, MEs, in the context of this review, can be any molecules as …

SiRNAs are strong gene-silencing agents that function in a target sequence-specific
manner. Although siRNAs might one day be used in therapy for intractable diseases such as …

Survivin stands out as one of the most specific cancer targets discovered to date. Although
single inhibition, eg through small interfering RNA (siRNA), has shown modest results in …

Gene-based therapies, defined as the transfer of genetic materials to treat a disease, can
potentially restore the function of the missing enzyme in individuals with inborn errors of …

A morpholine-based nucleotide analog was developed as a building block for hepatic
siRNA targeting and stabilization. Attachment of an asialoglycoprotein-binding GalNAc …

Cationic switchable lipids belong to the class of stimuli-responsive materials. When
incorporated in lipid nanoparticles (LNP), switchable LNP promote pH-triggered delivery of …