Development of copper nanoclusters for in vitro and in vivo theranostic applications

WF Lai, WT Wong, AL Rogach - Advanced Materials, 2020 - Wiley Online Library
Theranostics refers to the incorporation of therapeutic and diagnostic functions into one
material system. An important class of nanomaterials exploited for theranostics is metal …

Polymeric modification and its implication in drug delivery: poly-ε-caprolactone (PCL) as a model polymer

TK Dash, VB Konkimalla - Molecular pharmaceutics, 2012 - ACS Publications
Biodegradable polymers provided the opportunity to explore beyond conventional drug
delivery and turned out to be the focus of current drug delivery. In spite of availability of …

Self-assembled biodegradable amphiphilic PEG–PCL–lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene …

TK Endres, M Beck-Broichsitter, O Samsonova… - Biomaterials, 2011 - Elsevier
Amphiphilic PEG–PCL–PEI triblock copolymers self-assemble into nano-scaled, positively
charged, multifunctional carriers, suitable for drug and gene delivery. A set of block …

Composite liposome-PEI/nucleic acid lipopolyplexes for safe and efficient gene delivery and gene knockdown

SR Pinnapireddy, L Duse, B Strehlow, J Schäfer… - Colloids and surfaces B …, 2017 - Elsevier
Cytotoxicity is a major drawback impeding the therapeutic use of gene delivery and gene
down-regulation vehicles. Apart from cytotoxicity, rapid degradation and low cellular uptake …

Polyethyleneimine-based nanocarriers for gene delivery

X Wang, D Niu, C Hu, P Li - Current Pharmaceutical Design, 2015 - ingentaconnect.com
There is a tremendous progress in the design and synthesis of nano-scaled, non-viral
carriers in the previous two decades. The nanodelivery systems can significantly improve …

T‐cell targeted pulmonary siRNA delivery for the treatment of asthma

TWM Keil, D Baldassi, OM Merkel - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Despite the large number of drugs available for the treatment of asthma, in 5–10% of the
patients this disease is not well controlled. While most treatments palliate symptoms, those …

Folate receptor targeted delivery of siRNA and paclitaxel to ovarian cancer cells via folate conjugated triblock copolymer to overcome TLR4 driven chemotherapy …

SK Jones, V Lizzio, OM Merkel - Biomacromolecules, 2016 - ACS Publications
This paper focuses on the ability of a folate-decorated triblock copolymer to deliver a
targeted dose of siRNA in order to overcome chemotherapy resistance which can commonly …

Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration

J Li, Z Li, T Zhou, J Zhang, H Xia, H Li, J He… - International journal …, 2015 - Taylor & Francis
Purpose The cornea is a main barrier to drug penetration after topical application. The aim of
this study was to evaluate the abilities of micelles generated from a positively charged …

Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for Inhalation of Nano‐in‐Microparticles

TWM Keil, C Zimmermann, D Baldassi… - Advanced …, 2021 - Wiley Online Library
To develop stable and inhalable dry powder formulations with long shelf life, polyplexes
consisting of siRNA and a polyethylenimine (PEI)‐based block copolymer in presence of …

Branched aliphatic polyesters by ring-opening (co) polymerization

M Bednarek - Progress in Polymer Science, 2016 - Elsevier
The rapid development of biodegradable and biocompatible materials for biomedical
applications is reflected in the search for new methods for aliphatic polyester modification …