The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

AS Doghish, O Elazazy, HH Mohamed… - … -Research and Practice, 2023 - Elsevier
In recent years, microRNAs (miRNAs) have gained increased attention from researchers
around the globe. Although it is twenty nucleotides long, it can modulate several gene …

[HTML][HTML] Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system

B Zong, F Yu, X Zhang, Y Pang, W Zhao, P Sun… - Ageing Research …, 2023 - Elsevier
Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

[HTML][HTML] Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology

P Kukanja, CM Langseth, LAR Rodríguez-Kirby… - Cell, 2024 - cell.com
Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and
smoldering pathology. Although single-cell analyses provided insights into cytopathology …

Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells

B Zong, F Yu, X Zhang, W Zhao, S Li, L Li - Frontiers in immunology, 2023 - frontiersin.org
Multiple sclerosis (MS) is a prevalent neuroimmunological illness that leads to neurological
disability in young adults. Although the etiology of MS is heterogeneous, it is well …

CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis

J Beliën, S Swinnen, R D'hondt, LV de Juan… - Nature …, 2024 - nature.com
Multiple sclerosis (MS) is characterized by heterogeneity in disease course and prediction of
long-term outcome remains a major challenge. Here, we investigate five myeloid markers …

Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins

M Kim, H Choi, DJ Jang, HJ Kim, Y Sub… - Stem Cells …, 2024 - academic.oup.com
Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery
systems owing to their unique advantages, such as biocompatibility, immune tolerability, and …

The role of biogenic amines in the modulation of monocytes in autoimmune neuroinflammation.

O Belousova, A Lopatina, U Kuzmina… - Multiple Sclerosis and …, 2023 - Elsevier
Multiple sclerosis (MS) is inflammatory demyelinating and neurodegenerative disease of the
central nervous system (CNS) with autoimmune mechanism of development. The study of …

Exploring potential developmental origins of common neurodegenerative disorders

JP Catlin, CE Schaner Tooley - Biochemical Society …, 2024 - portlandpress.com
In the United States, it is now estimated that 6.7 million people over the age of 65 are
afflicted by Alzheimer's disease (AD), over 1 million people are living with Parkinson's …

Single cell-resolution in situ sequencing elucidates spatial dynamics of multiple sclerosis lesion and disease evolution

CM Langseth, P Kukanja, LA Rubio Rodríguez-Kirby… - bioRxiv, 2023 - biorxiv.org
Multiple sclerosis (MS) is a neurological disease characterised by multifocal lesions and
smouldering pathology. While single-cell analyses have provided insights into …

Brain-Immune interactions: Implication for Cognitive impairments in Alzheimer's Disease and autoimmune disorders

R Kadam, M Gupta, O Lazarov… - Journal of Leukocyte …, 2024 - academic.oup.com
Progressive memory loss and cognitive dysfunction, encompassing deficits in learning,
memory, problem-solving, spatial reasoning, verbal expression are characteristics of …