Tranexamic acid evidence and controversies: an illustrated review

N Relke, NLJ Chornenki… - Research and practice in …, 2021 - Wiley Online Library
Tranexamic acid (TXA) is an antifibrinolytic agent commonly used for the treatment or
prevention of bleeding. Indications for TXA are diverse, including heavy menstrual bleeding …

[HTML][HTML] Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled trials

HA Cheema, AB Ahmad, M Ehsan, A Shahid… - American Journal of …, 2023 - Elsevier
OBJECTIVE Tranexamic acid is a cost-effective intervention for the prevention of postpartum
hemorrhage among women who undergo cesarean delivery, but the evidence to support its …

Optimal use of intravenous tranexamic acid for hemorrhage prevention in pregnant women

HK Ahmadzia, NLC Luban, S Li, D Guo, A Miszta… - American journal of …, 2021 - Elsevier
Background Every 2 minutes, there is a pregnancy-related death worldwide, with one-third
caused by severe postpartum hemorrhage. Although international trials demonstrated the …

The WOMAN trial: clinical and contextual factors surrounding the deaths of 483 women following post-partum haemorrhage in developing countries

R Picetti, L Miller, H Shakur-Still, T Pepple… - BMC Pregnancy and …, 2020 - Springer
Background Post-partum haemorrhage (PPH) is a leading cause of maternal death
worldwide. The WOMAN trial assessed the effects of tranexamic acid (TXA) on death and …

Tranexamic acid and obstetric hemorrhage: give empirically or selectively?

A Shander, M Javidroozi, L Sentilhes - International Journal of Obstetric …, 2021 - Elsevier
Antifibrinolytic agents such as tranexamic acid (TXA) inhibit the fibrinolytic pathway and
protect blood clots from being degraded, thereby promoting hemostasis. They have been …

[HTML][HTML] Tranexamic acid for post-partum haemorrhage: What, who and when

A Brenner, K Ker, H Shakur-Still, I Roberts - Best Practice & Research …, 2019 - Elsevier
Tranexamic acid reduces bleeding by inhibiting the breakdown of blood clots. It is cost-
effective and heat-stable with a long shelf life. In the WOMAN trial, tranexamic acid reduced …

Tranexamic acid for postpartum hemorrhage treatment in low-resource settings: A rapid scoping review

NT Tran, S Bar-Zeev, C Schulte-Hillen… - International Journal of …, 2022 - mdpi.com
Tranexamic acid (TXA) effectively reduces bleeding in women with postpartum hemorrhage
(PPH) in hospital settings. To guide policies and practices, this rapid scoping review …

The role of tranexamic acid in the management of postpartum haemorrhage

AS Bouthors, S Gilliot, L Sentilhes, B Hennart… - Best Practice & …, 2022 - Elsevier
In the last decades, tranexamic acid (TXA) has emerged as an essential tool in blood loss
management in obstetrics. TXA prophylaxis for postpartum haemorrhage (PPH) has been …

Improving development of drug treatments for pregnant women and the fetus

AL David, H Ahmadzia, R Ashcroft… - … innovation & regulatory …, 2022 - Springer
The exclusion of pregnant populations, women of reproductive age, and the fetus from
clinical trials of therapeutics is a major global public health issue. It is also a problem of …

Emergencies in obstetric anaesthesia: a narrative review

CH Prior, CEG Burlinson, A Chau - Anaesthesia, 2022 - Wiley Online Library
We conducted a narrative review in six areas of obstetric emergencies: category‐1
caesarean section; difficult and failed airway; massive obstetric haemorrhage; hypertensive …