Context.—Chordomas are uncommon malignant neoplasms with notochordal differentiation
encountered by neuropathologists, bone/soft tissue pathologists, and general surgical …

Chordoma is a low-grade notochordal tumor of the skull base, mobile spine and sacrum
which behaves malignantly and confers a poor prognosis despite indolent growth patterns …

Chordoma is a complex disease because of its rarity, biological heterogeneity and peculiar
clinical behaviour. Despite the progress done, the outcome in this disease remains …

The last decade has seen the majority of primary bone tumor subtypes become defined by
molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p. G34W) …

Objectives: Chordoma is a rare bone malignancy that affects the spine and skull base.
Treatment dilemma leads to a high rate of local relapse and distant metastases. Molecular …

Chordoma is a rare tumor that occurs along the axial spine in pediatrics and adults, with an
incidence of approximately 350 cases per year in the United States. While typically …

Simple Summary Chordomas and chondrosarcomas are rare tumors that can occur within
the skull base and spinal column and are often resistant to chemotherapy and radiation …

Expression of the transcription factor brachyury (TBXT) is normally restricted to the embryo,
and its silencing is epigenetically regulated. TBXT promotes mesenchymal transition in a …

Objective: chordomas are rare bone tumors with few therapeutic options. Skull base and
sacrum are the two most common origin sites. Immunotherapies are emerging as the most …

Chordoma is a devastating rare cancer that affects one in a million people. With a mean-
survival of just 6 years and no approved medicines, the primary treatments are surgery and …