Background With progress on both the theoretical and the computational fronts the use of
spline modelling has become an established tool in statistical regression analysis. An …

Data that have a multilevel structure occur frequently across a range of disciplines, including
epidemiology, health services research, public health, education and sociology. We …

Background Isocitrate dehydrogenase (IDH)–mutant grade 2 gliomas are malignant brain
tumors that cause considerable disability and premature death. Vorasidenib, an oral brain …

Background Survival analysis is a cornerstone of medical research, enabling the
assessment of clinical outcomes for disease progression and treatment efficiency. Despite …

Using pre-treatment gene expression, protein/phosphoprotein, and clinical data from the I-
SPY2 neoadjuvant platform trial (NCT01042379), we create alternative breast cancer …

Objective To establish whether there is any change in mortality from infection with a new
variant of SARS-CoV-2, designated a variant of concern (VOC-202012/1) in December …

Background Long-term exposure to ambient air pollution has been associated with
premature mortality, but associations at concentrations lower than current annual limit …

Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4
and PD-1 is associated with clinical benefit across tumor types, but also a high rate of …

DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …

Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …