How I treat cytopenias after CAR T-cell therapy
Increasing use of chimeric antigen receptor T-cell therapy (CAR-T) has unveiled diverse
toxicities warranting specific recognition and management. Cytopenias occurring after CAR …
toxicities warranting specific recognition and management. Cytopenias occurring after CAR …
[HTML][HTML] Significant risk of graft-versus-host disease with exposure to checkpoint inhibitors before and after allogeneic transplantation
Investigators are using checkpoint inhibitors (CPIs) to treat aggressive hematologic
malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo …
malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo …
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
NR Mathew, F Baumgartner, L Braun, D O'Sullivan… - Nature medicine, 2018 - nature.com
Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …
Graft‐versus‐host disease risk after chimeric antigen receptor T‐cell therapy: the diametric opposition of T cells
Chimeric antigen receptor (CAR) T‐cell therapy has brought a paradigm shift in the
management of haematological malignancies and has opened novel avenues of …
management of haematological malignancies and has opened novel avenues of …
Acute graft-versus-host disease of the gut: considerations for the gastroenterologist
S Naymagon, L Naymagon, SY Wong, HM Ko… - Nature Reviews …, 2017 - nature.com
Haematopoietic stem cell transplantation (HSCT) is central to the management of many
haematological disorders. A frequent complication of HSCT is acute graft-versus-host …
haematological disorders. A frequent complication of HSCT is acute graft-versus-host …
Immune landscape after allo-HSCT: TIGIT-and CD161-expressing CD4 T cells are associated with subsequent leukemia relapse
V Gournay, N Vallet, V Peux, K Vera… - Blood, The Journal …, 2022 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective
treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft …
treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft …
[HTML][HTML] CC-486 maintenance after stem cell transplantation in patients with acute myeloid leukemia or myelodysplastic syndromes
M De Lima, B Oran, RE Champlin… - Biology of Blood and …, 2018 - Elsevier
Relapse is the main cause of treatment failure after allogeneic stem cell transplant (alloSCT)
in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Injectable …
in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Injectable …
Minimal residual disease in acute myeloid leukaemia
CS Hourigan, JE Karp - Nature reviews Clinical oncology, 2013 - nature.com
Technological advances in the laboratory have led to substantial improvements in clinical
decision making through the introduction of pretreatment prognostic risk stratification factors …
decision making through the introduction of pretreatment prognostic risk stratification factors …
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans
FM Uhl, S Chen, D O'Sullivan… - Science translational …, 2020 - science.org
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation
(allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after …
(allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after …
[HTML][HTML] Phase II study of haploidentical natural killer cell infusion for treatment of relapsed or persistent myeloid malignancies following allogeneic hematopoietic cell …
BC Shaffer, JB Le Luduec, C Forlenza… - Biology of Blood and …, 2016 - Elsevier
We conducted a phase 2 study to determine the efficacy of HLA-haploidentical related donor
natural killer (NK) cells after cyclophosphamide-based lymphodepletion in patients with …
natural killer (NK) cells after cyclophosphamide-based lymphodepletion in patients with …