How I treat cytopenias after CAR T-cell therapy

T Jain, TS Olson, FL Locke - … Journal of the American Society of …, 2023 - ashpublications.org
Increasing use of chimeric antigen receptor T-cell therapy (CAR-T) has unveiled diverse
toxicities warranting specific recognition and management. Cytopenias occurring after CAR …

[HTML][HTML] Significant risk of graft-versus-host disease with exposure to checkpoint inhibitors before and after allogeneic transplantation

A Ijaz, AY Khan, SU Malik, W Faridi, MA Fraz… - Biology of Blood and …, 2019 - Elsevier
Investigators are using checkpoint inhibitors (CPIs) to treat aggressive hematologic
malignancies in patients undergoing allogeneic hematopoietic stem cell transplantation (allo …

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

NR Mathew, F Baumgartner, L Braun, D O'Sullivan… - Nature medicine, 2018 - nature.com
Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …

Graft‐versus‐host disease risk after chimeric antigen receptor T‐cell therapy: the diametric opposition of T cells

K Sanber, B Savani, T Jain - British journal of haematology, 2021 - Wiley Online Library
Chimeric antigen receptor (CAR) T‐cell therapy has brought a paradigm shift in the
management of haematological malignancies and has opened novel avenues of …

Acute graft-versus-host disease of the gut: considerations for the gastroenterologist

S Naymagon, L Naymagon, SY Wong, HM Ko… - Nature Reviews …, 2017 - nature.com
Haematopoietic stem cell transplantation (HSCT) is central to the management of many
haematological disorders. A frequent complication of HSCT is acute graft-versus-host …

Immune landscape after allo-HSCT: TIGIT-and CD161-expressing CD4 T cells are associated with subsequent leukemia relapse

V Gournay, N Vallet, V Peux, K Vera… - Blood, The Journal …, 2022 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective
treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft …

[HTML][HTML] CC-486 maintenance after stem cell transplantation in patients with acute myeloid leukemia or myelodysplastic syndromes

M De Lima, B Oran, RE Champlin… - Biology of Blood and …, 2018 - Elsevier
Relapse is the main cause of treatment failure after allogeneic stem cell transplant (alloSCT)
in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Injectable …

Minimal residual disease in acute myeloid leukaemia

CS Hourigan, JE Karp - Nature reviews Clinical oncology, 2013 - nature.com
Technological advances in the laboratory have led to substantial improvements in clinical
decision making through the introduction of pretreatment prognostic risk stratification factors …

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

FM Uhl, S Chen, D O'Sullivan… - Science translational …, 2020 - science.org
Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation
(allo-HCT) has a dismal prognosis. We found that T cells of patients relapsing with AML after …

[HTML][HTML] Phase II study of haploidentical natural killer cell infusion for treatment of relapsed or persistent myeloid malignancies following allogeneic hematopoietic cell …

BC Shaffer, JB Le Luduec, C Forlenza… - Biology of Blood and …, 2016 - Elsevier
We conducted a phase 2 study to determine the efficacy of HLA-haploidentical related donor
natural killer (NK) cells after cyclophosphamide-based lymphodepletion in patients with …