Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-
resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and …

Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …

The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator
superfamily (MFS) of membrane transporters. Crystal structures have recently revealed how …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …