Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …

The recent success of mRNA therapeutics against pathogenic infections has increased
interest in their use for other human diseases including cancer. However, the precise …

Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA
vaccines are an attractive and powerful immunotherapeutic platform against cancer because …

Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

An unheard mobilization of resources to find SARS-CoV-2 vaccines and therapies has been
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …

Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …

Functional nucleic acid (NA)-based drugs have a broad range of applications since they
allow the alteration and control of gene/protein expression patterns in cells. In principle …