High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …

Novel endoscopic biophotonic diagnostic technologies have the potential to non-invasively
detect the interior of a hollow organ or cavity of the human body with subcellular resolution …

Despite the unique advantages of optical microscopy for molecular specific high resolution
imaging of living structure in both space and time, current applications are mostly limited to …

With recent advances in cancer therapeutics, there is a great need for improved imaging
methods for characterizing cancer onset and progression in a quantitative and actionable …

Women with high breast density are at notably greater risk for breast cancer. Moreover,
breast tumor tissue can be up to 10-fold stiffer than normal tissue, containing dense …

Cancer is a multi-step process where normal cells become transformed, grow, and may
disseminate to establish new lesions within the body. In recent years, the physical properties …

The combination of intravital dye, methylene blue (MB), with molecular cancer marker, pH
low insertion peptide (pHLIP) conjugated with fluorescent Alexa532 (Alexa532‐pHLIP), was …

Introduction Breast cancer (BC), the most frequently diagnosed malignancy among women
worldwide, presents a public health challenge and affects mortality rates. Breast‐conserving …

Purpose Various laboratory sources have recently achieved progress in implementing deep
learning models on biomedical optical imaging of soft biological tissues. The highly …

Despite tremendous advancements in in vivo imaging modalities, there remains substantial
uncertainty with respect to tumor delineation on in these images. Histopathology remains the …