Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal
loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …

Neurodegenerative diseases are a major public health problem worldwide with a wide
spectrum of symptoms and physiological effects. It has been long reported that the …

The nicotinic acetylcholine receptor (nAChR) belongs to a superfamily of pentameric ligand-
gated ion channels involved in many physiologic and pathologic processes. Among …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …

The clinical development of selective alpha-7 nicotinic acetylcholine receptor (α7 nAChR)
agonists has hitherto been focused on disorders characterized by cognitive deficits (eg …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Nicotinic acetylcholine receptors (nAChRs) are actively being investigated as therapeutic
targets for the treatment of pain and inflammation, but despite more than 30 years of …

Despite recent advances in understanding the causes of epilepsy, especially the genetic,
comprehending the biological mechanisms that lead to the epileptic phenotype remains …

The α7 nicotinic acetylcholine receptor (α7 nAChR) is highly expressed in the brain, where it
maintains various neuronal functions including (but not limited to) learning and memory. In …