An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The
substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a …

Abstract Aurora kinase A (Aurora-A), a serine/threonine kinase, plays a pivotal role in
various cellular processes, including mitotic entry, centrosome maturation and spindle …

Inflammasomes are essential components of the innate immune system and its defense
against infections, whereas the dysregulation of inflammasome activation has a detrimental …

Abstract Ubiquitin-specific protease 3 (USP3) plays an important role in the progression of
various tumors. However, the role of USP3 in osteosarcoma (OS) remains poorly …

Objective LncRNA PART1 has been confirmed related to multiple cancer bioactivities
mediated with vascular endothelial growth factor signaling. Nevertheless, the role of …

Ubiquitination is one of the most significant post-translational modifications that regulate
almost all physiological processes like cell proliferation, autophagy, apoptosis, and cell …

Laryngeal cancer is a usual malignant tumor of the head and neck. The role and mechanism
of deubiquitinase USP21 in laryngeal cancer are still unclear. We aimed to explore whether …

Background Renal cell carcinoma (RCC) is a common malignant tumor of the urinary
system. Angiogenesis is a main contributing factor for tumorigenesis. E74-like transcription …

Ubiquitination and deubiquitylation are pivotal posttranslational modifications essential for
regulating cellular protein homeostasis and are implicated in the development of human …

Microbial products, such as lipopolysaccharide (LPS), can elicit efficient innate immune
responses against invading pathogens. However, priming with LPS can induce a form of …