Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer
(PCa) growth. However, how FOXA1 levels are regulated remains elusive and its …

The linear regression model cannot be fitted to high-dimensional data, as the high-
dimensionality brings about empirical non-identifiability. Penalized regression overcomes …

Molecular heterogeneity characterizes tumours' evolution and adaptation and, because of its
dynamics and continuous changes under external pressure, it is one of the major causes of …

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

Background Prostate cancer (PCa) is a leading reason of death in men and the most
diagnosed malignancies in the western countries at the present time. After radical …

Radiotherapy is a non-invasive standard treatment for prostate cancer (PC). However, PC
develops radio-resistance, highlighting a need for agents to improve radiotherapy response …

The widespread application of antiandrogen therapies has aroused a significant increase in
the incidence of NEPC, a lethal form of the disease lacking efficient clinical treatments. Here …

Background Neuroblastoma is characterized by substantial clinical heterogeneity. Despite
intensive treatment, the survival rates of high-risk neuroblastoma patients are still …

Molecular characterization of genome-wide association study (GWAS) loci can uncover key
genes and biological mechanisms underpinning complex traits and diseases. Here we …

Immunotherapy is poised to become an increasingly utilized therapy in the treatment of
cancer. However, several abnormalities in the tumor microenvironment (TME) that can …