Abstract Background Cancer-associated fibroblasts (CAFs) are an essential component of
the tumor immune microenvironment that are involved in extracellular matrix (ECM) …

Prostate cancer (PCa) is a hormone-dependent tumor characterized by an extremely
heterogeneous prognosis. Despite recent advances in partially uncovering some of the …

Prostate cancer (PCa) is the leading cause of cancer-associated mortality in men, and new
biomarkers are still needed. The expression pattern and protein tissue localization of …

Some prostate cancers (PCas) are histo-pathologically grouped within the same Gleason
Grade (GG), but can differ significantly in outcome. Herein, we aimed at identifying molecular …

Background Distinguishing between true indolent and potentially life-threatening prostate
cancer is challenging in tumours displaying clinicopathologic features associated with low or …

Prostate cancer (PCa) is characterised by androgen dependency. Unfortunately, under anti-
androgen treatment pressure, castration-resistant prostate cancer (CRPC) emerges …

Prostate cancer (PCa) that progresses after androgen deprivation therapy (ADT) remains
incurable. The underlying mechanisms that account for the ultimate emergence of resistance …

Tumor-adjacent normal (TAN) tissues, which constitute tumor microenvironment and are
different from healthy tissues, provide critical information at molecular levels that can be …

Androgen receptors (ARs) play key roles in prostate cancer (PCa) progression and
castration-resistant prostate cancer (CRPC) resistance to drug therapy. SET and MYND …

Background A critical problem in the clinical management of prostate cancer is that it is
highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not …