Hypothalamic control of energy balance: different peptides, different functions
SF Leibowitz, KE Wortley - Peptides, 2004 - Elsevier
Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …
periphery. A key component of this system is the hypothalamus. Over the past two decades …
Anti-obesity drugs: a critical review of current therapies and future opportunities
JC Clapham, JRS Arch, M Tadayyon - Pharmacology & therapeutics, 2001 - Elsevier
The last 25 years have seen a great increase in the incidence of obesity, both in the Western
world and in developing third world countries. Despite the seeming inexorable progression …
world and in developing third world countries. Despite the seeming inexorable progression …
Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord
M Hallbeck, D Larhammar… - Journal of Comparative …, 2001 - Wiley Online Library
The paraventricular hypothalamic nucleus (PVH) exerts many of its regulatory functions
through projections to spinal cord neurons that control autonomic and sensory functions. By …
through projections to spinal cord neurons that control autonomic and sensory functions. By …
Different forms of obesity as a function of diet composition
JT Dourmashkin, GQ Chang, EC Gayles… - International journal of …, 2005 - nature.com
OBJECTIVE: To characterize the phenotype of obesity on a high-carbohydrate diet (HCD) as
compared to a high-fat diet (HFD) or moderate-fat diet (MFD). METHODS AND …
compared to a high-fat diet (HFD) or moderate-fat diet (MFD). METHODS AND …
Distinct phenotypes of obesity-prone AKR/J, DBA2J and C57BL/6J mice compared to control strains
J Alexander, GQ Chang, JT Dourmashkin… - International journal of …, 2006 - nature.com
Objective: To characterize and compare three obesity-prone inbred strains, AKR/J, DBA/2J
and C57BL/6J, to three control strains, C3H/HeJ, BALB/cByJ and C57L/J, selected based on …
and C57BL/6J, to three control strains, C3H/HeJ, BALB/cByJ and C57L/J, selected based on …
Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action
A Laque, Y Zhang, S Gettys… - American Journal …, 2013 - journals.physiology.org
Leptin acts centrally via leptin receptor (LepRb)-expressing neurons to regulate food intake,
energy expenditure, and other physiological functions. LepRb neurons are found throughout …
energy expenditure, and other physiological functions. LepRb neurons are found throughout …
Galanin-containing neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain.
A Akabayashi, JI Koenig, Y Watanabe… - Proceedings of the …, 1994 - National Acad Sciences
The physiological function of the peptide galanin (Gal) remains to be established. It is known
to exist in high concentrations within the hypothalamus and to modulate the secretion of …
to exist in high concentrations within the hypothalamus and to modulate the secretion of …
Galanin antagonists block galanin‐induced feeding in the hypothalamus and amygdala of the rat
RL Corwin, JK Robinson… - European Journal of …, 1993 - Wiley Online Library
Galanin significantly increased food intake when microinjected into the region of the central
nucleus of the amygdala as well as into the paraventricular nucleus of the hypothalamus. In …
nucleus of the amygdala as well as into the paraventricular nucleus of the hypothalamus. In …
Obesity on a high-fat diet: role of hypothalamic galanin in neurons of the anterior paraventricular nucleus projecting to the median eminence
SF Leibowitz, A Akabayashi, J Wang - Journal of Neuroscience, 1998 - Soc Neuroscience
Previous studies have suggested that the peptide galanin (GAL) in the hypothalamus is
related to the preference of an animal for dietary fat. The present report investigates this …
related to the preference of an animal for dietary fat. The present report investigates this …
Behavioral neuroscience and obesity
SF Leibowitz, BG Hoebel - Handbook of obesity, 2003 - taylorfrancis.com
An animal's brain monitors energy in the environment and within the body and then adjusts
eating behavior, energy utilization, and fat stores to maintain a balance. This chapter will …
eating behavior, energy utilization, and fat stores to maintain a balance. This chapter will …