Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

The use of drug nanocrystals in the drug formulation is increasing due to the large number of
poorly water-soluble drug compounds synthetized and due to the advantages brought by the …

Cocrystals are crystalline single phase materials composed of two or more different
molecular and/or ionic compounds generally in a stoichiometric ratio which are neither …

Pharmaceutical cocrystallization affords an opportunity to modify the physicochemical
properties of a solid-state drug without covalent modification of its molecular structure. This …

Pharmaceutical co-crystals are novel class of pharmaceutical substances, which possess an
apparent probability of advancement of polished physical properties offering stable and …

Stability is an essential quality attribute of any pharmaceutical formulation. Poor stability can
change the color and physical appearance of a drug, directly impacting the patient's …

Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid
sate properties of drug substances like solubility and dissolution. The objective of the …