Many studies have provided evidence for the hypothesis that size at birth is related to the
risk of developing disease in later life. In particular, links are well established between …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …

Depending on the definitions used, up to 10% of all live-born neonates are small for
gestational age (SGA). Although the vast majority of these children show catch-up growth by …

Type 2 diabetes mellitus is a multifactorial disease, due to decreased glucose peripheral
uptake, and increased hepatic glucose production, due to reduced both insulin secretion …

The intrauterine growth restricted (IUGR) fetus develops unique metabolic adaptations in
response to exposure to reduced nutrient supply. These adaptations provide survival value …

Intrauterine growth restriction (IUGR) has been defined in several ways, but in general
describes a condition in which the fetus exhibits poor growth in utero. This complication of …

This article reviews the evidence for fetal and early origins of type 2 diabetes, insulin
resistance, dyslipidaemia and obesity. Particular emphasis is given to the role of adipose …

Emerging research has highlighted the importance of leptin in fetal growth and development
independent of its essential role in the maintenance of hunger and satiety through the …

To date, we have little knowledge on the overall metabolic status of neonates with
intrauterine growth retardation (IUGR). In the last few years, the analysis of metabolomics …

Human fetuses with severe intrauterine growth restriction (IUGR) have less pancreatic
endocrine tissue and exhibit β-cell dysfunction, which may limit β-cell function in later life …