LAG-3 as the third checkpoint inhibitor
V Aggarwal, CJ Workman, DAA Vignali - Nature immunology, 2023 - nature.com
Abstract Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly
expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target, with more …
expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target, with more …
[HTML][HTML] LAG-3: from molecular functions to clinical applications
T Maruhashi, D Sugiura, I Okazaki… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
To prevent the destruction of tissues owing to excessive and/or inappropriate immune
responses, immune cells are under strict check by various regulatory mechanisms at …
responses, immune cells are under strict check by various regulatory mechanisms at …
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
C Guy, DM Mitrea, PC Chou, J Temirov, KM Vignali… - Nature …, 2022 - nature.com
LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-
targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function …
targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function …
[HTML][HTML] Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
T Maruhashi, D Sugiura, I Okazaki, K Shimizu… - Immunity, 2022 - cell.com
Summary Lymphocyte activation gene-3 (LAG-3) is a potent inhibitory co-receptor; yet, its
functional ligand remains elusive, with distinct potential ligands identified. Here, we …
functional ligand remains elusive, with distinct potential ligands identified. Here, we …
[HTML][HTML] LAG3's enigmatic mechanism of action
CG Graydon, S Mohideen, KR Fowke - Frontiers in immunology, 2021 - frontiersin.org
LAG3 is an important immune checkpoint with relevance in cancer, infectious disease and
autoimmunity. However, despite LAG3's role in immune exhaustion and the great potential …
autoimmunity. However, despite LAG3's role in immune exhaustion and the great potential …
[HTML][HTML] The next-generation immune checkpoint LAG-3 and its therapeutic potential in oncology: third time'sa charm
Q Lecocq, M Keyaerts, N Devoogdt… - International journal of …, 2020 - mdpi.com
The blockade of immune checkpoints (ICPs), such as cytotoxic T lymphocyte associated
protein-4 (CTLA-4) and programmed death-1 (PD-1) and its ligand (PD-L1), has propelled …
protein-4 (CTLA-4) and programmed death-1 (PD-1) and its ligand (PD-L1), has propelled …
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition
The immune checkpoint receptor lymphocyte activation gene 3 protein (LAG3) inhibits T cell
function upon binding to major histocompatibility complex class II (MHC class II) or …
function upon binding to major histocompatibility complex class II (MHC class II) or …
[HTML][HTML] Understanding LAG-3 signaling
Lymphocyte activation gene 3 (LAG-3) is a cell surface inhibitory receptor with multiple
biological activities over T cell activation and effector functions. LAG-3 plays a regulatory …
biological activities over T cell activation and effector functions. LAG-3 plays a regulatory …
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation
Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …
[HTML][HTML] Clinical landscape of LAG-3-targeted therapy
Highlights•LAG-3 is a highly important next-generation immune checkpoint molecule.•Ninety-
seven clinical trials are evaluating at least 16 LAG-3-targeting molecules.•Here we identify …
seven clinical trials are evaluating at least 16 LAG-3-targeting molecules.•Here we identify …