Immunotherapy is a new type of tumor treatment after surgery, radiotherapy and
chemotherapy, which can be used to manage and destroy tumor cells through activating or …

Breast cancer (BC) is the most common cancer in women worldwide. Although substantial
progress has been made in the diagnosis and treatment of breast cancer, the efficacy and …

Regulatory T cells (Tregs) are among the most abundant suppressive cells, which infiltrate
and accumulate in the tumor microenvironment, leading to tumor escape by inducing anergy …

Immunotherapy is based on the systemic immunity activation against malignacies, which is
becoming one of the most promising modalities in solid tumor therapy. Unfortunately, the …

This comprehensive review elucidates the intricate roles of long non-coding RNAs
(lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of …

The advent of immunotherapy, specifically of immune checkpoint inhibitors (ICIs), for the
treatment of solid tumors has deeply transformed therapeutic algorithms in medical …

Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

Currently, checkpoint inhibitor‐based immunotherapy has emerged as prevailing treatment
modality for diverse cancers. However, immunotherapy as a first‐line therapy has not …

Introduction Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid
metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown …

Regulatory T cells (Tregs), possess a pivotal function in the maintenance of immune
homeostasis. The dysregulated activity of Tregs has been associated with the onset of …